RESUMO
Abstract: Background: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed. Objective: To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF. Methods: This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death. Results: One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p = 0.004 / 95%CI: 1.0 - 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification. Study Limitations: Small sample and its retrospective analysis. Conclusions: Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use.
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Cutâneas/patologia , Micose Fungoide/patologia , Prognóstico , Neoplasias Cutâneas/mortalidade , Brasil/epidemiologia , Estudos Transversais , Taxa de Sobrevida , Estudos Retrospectivos , Seguimentos , Linfoma Cutâneo de Células T/mortalidade , Linfoma Cutâneo de Células T/patologia , Micose Fungoide/mortalidade , Síndrome de Sézary/patologia , Progressão da Doença , Estadiamento de NeoplasiasRESUMO
BACKGROUND: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed. OBJECTIVE: To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF. METHODS: This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death. RESULTS: One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p = 0.004 / 95%CI: 1.0 - 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification. STUDY LIMITATIONS: Small sample and its retrospective analysis. CONCLUSIONS: Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use.
Assuntos
Micose Fungoide/patologia , Neoplasias Cutâneas/patologia , Brasil/epidemiologia , Estudos Transversais , Progressão da Doença , Seguimentos , Humanos , Linfoma Cutâneo de Células T/mortalidade , Linfoma Cutâneo de Células T/patologia , Masculino , Pessoa de Meia-Idade , Micose Fungoide/mortalidade , Estadiamento de Neoplasias , Prognóstico , Estudos Retrospectivos , Síndrome de Sézary/patologia , Neoplasias Cutâneas/mortalidade , Taxa de SobrevidaRESUMO
Neste artigo a abordagem terapêutica atual da sífilis é revisada, baseada em seus estágios clínicos e laboratoriais. Resumem-se suas opções terapêuticas e controle de cura, obtendo-se assim o conhecimento atual necessário para a melhor atuação no atendimento médico
